E-001
Ecgonine methyl ester solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
Synonym(s):
Ecgonine methyl ester solution
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About This Item
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
drug control
Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
concentration
1.0 mg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
InChI
1S/C10H17NO3/c1-11-6-3-4-7(11)9(8(12)5-6)10(13)14-2/h6-9,12H,3-5H2,1-2H3/t6?,7?,8-,9+/m0/s1
InChI key
QIQNNBXHAYSQRY-ABIFROTESA-N
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General description
A certified Snap-N-Spike® solution standard suitable for use in LC/MS or GC/MS testing applications including forensic analysis, urine drug testing, and clinical toxicology. Ecgonine methyl ester is a major urinary metabolite of cocaine, a popular illicit drug well known as "crack" or the free base form of cocaine that can be smoked.
Application
- Ecgonine methyl ester standard:The site- and species-specific hydrolysis rates of cocaine, demonstrating the importance of Ecgonine methyl ester as a reference standard in understanding cocaine metabolism pathways, aiding in pharmaceutical and forensic applications (Szocs et al., 2017).
- Mass spectrometry reagent:Sensitive fluorescence probe was developed using molecularly imprinted polymers and Mn-doped ZnS quantum dots for the determination of cocaine and metabolites in urine, highlighting the use of Ecgonine methyl ester as a crucial mass spectrometry reagent for drug testing (Chantada-Vazquez et al., 2016).
- Cocaine metabolite analysis:Magnetic molecularly imprinted polymers were developed for solid phase extraction of cocaine and metabolites in urine before high-performance liquid chromatography - tandem mass spectrometry, illustrating the essential role of Ecgonine methyl ester in the selective detection and quantification of cocaine metabolites (J Sanchez-Gonzzlez, et al., 2016).
- Biochemical research chemicals:Porous membrane-protected molecularly imprinted polymer micro-solid-phase extraction method for analyzing urinary cocaine and its metabolites, validating Ecgonine methyl ester′s utility in biochemical and pharmacological studies (Sanchez-Gonzalez et al., 2015).
- Forensic toxicology supplies:Employed peptides to trap cocaine, using solid phase extraction followed by liquid chromatography-mass spectrometry in plasma samples, underlining the application of Ecgonine methyl ester in forensic toxicology for precise and accurate drug monitoring (Mascini et al., 2013).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
35.6 °F - closed cup
Flash Point(C)
2 °C - closed cup
Certificates of Analysis (COA)
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Marta Concheiro et al.
Journal of analytical toxicology, 31(9), 573-580 (2007-12-21)
A method, using 0.5 mL of urine, was developed for the simultaneous determination of ecgonine methyl ester, benzoylecgonine, morphine, codeine, 6-acetylmorphine, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and d-lysergic acid diethylamide (LSD). The analysis was performed by
C Pistos et al.
Rapid communications in mass spectrometry : RCM, 23(23), 3772-3780 (2009-11-11)
At present, no official criteria exist for drug identification using single quadrupole mass spectrometers although the European Union (EU) criteria for compound identification have been adopted. These criteria are evaluated with respect to the confirmation of cocaine and its metabolites
Rosa Cordero et al.
Journal of analytical toxicology, 34(9), 543-548 (2010-11-16)
The concentrations and ratios of cocaine, benzoylecgonine (BE), and ecgoninemethylester (EME) in 360 head hair segments and 34 pubic hair samples collected at coroner's postmortem examinations were reviewed. The cases included diverse histories and causes/circumstances of death. The hair was
Xiaobo Wang et al.
Se pu = Chinese journal of chromatography, 28(7), 673-676 (2010-11-05)
A method was developed for the simultaneous determination of cocaine (COC) and its metabolite ecgonine methyl ester (EME) in human blood using gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID). The blood sample was prepared by microwave extraction
Karl B Scheidweiler et al.
Therapeutic drug monitoring, 32(5), 628-637 (2010-09-04)
Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation. While residing on a closed research unit for up to 10 weeks
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