A-075
Androstenedione solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C19H26O2
CAS Number:
Molecular Weight:
286.41
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
O=C1C=C2CCC3C4C(C(CC4)=O)(C)CCC3C2(C)CC1
InChI
1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3
InChI key
AEMFNILZOJDQLW-UHFFFAOYSA-N
General description
Androstenedione is a hormone and intermediate in the biochemical pathway for producing testosterone, estrone, and estradiol. This Certified Spiking Solution® is suitable for use as starting material in linearity standards, calibrators, and controls for numerous LC/MS and GC/MS applications in endocrinology, clinical chemistry, neonatal screening, and sports testing.
Application
<ul>
<li><strong>Steroid biosynthesis studies:</strong> The utility of androstenedione solution in dried blood spot analysis via liquid chromatography tandem mass spectrometry is highlighted, providing a method applicable for newborn screening for congenital adrenal hyperplasia and other steroid-related disorders (Zhan et al., 2022).</li>
<li><strong>Hormone precursor biochemical research:</strong> A method for the simultaneous measurement of testosterone, androstenedione, and dehydroepiandrosterone in human serum using liquid chromatography-tandem mass spectrometry was developed, supporting research in hormone biosynthesis and metabolism (Xu et al., 2017).</li>
<li><strong>Anabolic steroid research:</strong> A study on the application of a UHPLC-MS/MS method for the determination of 17 steroidal hormones, including androstenedione, in equine serum, is crucial for advancing research in doping and physiological studies (Genangeli et al., 2017).
</ul>
<li><strong>Steroid biosynthesis studies:</strong> The utility of androstenedione solution in dried blood spot analysis via liquid chromatography tandem mass spectrometry is highlighted, providing a method applicable for newborn screening for congenital adrenal hyperplasia and other steroid-related disorders (Zhan et al., 2022).</li>
<li><strong>Hormone precursor biochemical research:</strong> A method for the simultaneous measurement of testosterone, androstenedione, and dehydroepiandrosterone in human serum using liquid chromatography-tandem mass spectrometry was developed, supporting research in hormone biosynthesis and metabolism (Xu et al., 2017).</li>
<li><strong>Anabolic steroid research:</strong> A study on the application of a UHPLC-MS/MS method for the determination of 17 steroidal hormones, including androstenedione, in equine serum, is crucial for advancing research in doping and physiological studies (Genangeli et al., 2017).
</ul>
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
35.6 °F - closed cup
Flash Point(C)
2 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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S N Schauer et al.
Theriogenology, 79(3), 409-416 (2012-12-04)
There is evidence in several species that high circulating LH concentrations can interfere with normal follicle development and ovulation. In the mare, high LH levels after induction of luteolysis with PGF(2α) have been temporally associated with an increased incidence of
Dalei Zhang et al.
BioMed research international, 2013, 301540-301540 (2013-03-14)
Bone marrow stem cells (BMSCs) have the capacity to differentiate into mature cell types of multiple tissues. Thus, they represent an alternative source for organ-specific cell replacement therapy in degenerative diseases. In this study, we demonstrated that female rat BMSCs
Ewa Łucja Gregoraszczuk et al.
Reproduction (Cambridge, England), 145(3), 311-317 (2013-04-13)
Evidence from both clinical and animal studies suggests that exposure to excess androgens results in cyst formation. The present in vitro study assessed the effects of supraphysiological concentrations of leptin (20 and 40 ng/ml) on progesterone (P(4)), androstenedione androstendione (A(4))
Hidetaka Tasaki et al.
Theriogenology, 79(5), 809-814 (2013-01-26)
Antrum formation and estradiol (E2) secretion occur during early folliculogenesis. The objective was to determine the role of E2 in antrum formation of oocyte-granulosa cell complexes (OGCs) derived from porcine preantral follicles (PAFs). Supplementation of the culture medium with E2
Floriane Guibert et al.
Proceedings. Biological sciences, 280(1753), 20122368-20122368 (2012-12-21)
The prenatal environment is a source of phenotypic variability influencing the animal's characteristics. Prenatal stress affects not only the development of offspring, but also that of the following generation. Such effects have been best documented in mammals but can also
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