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857134P

Avanti

18:1 Hemi BMP (S,R)

sn-(3-oleoyl-2-hydroxy)-glycerol-1-phospho-sn-3′-(1′,2′-dioleoyl)-glycerol (ammonium salt), powder

Synonym(s):

110734

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About This Item

Empirical Formula (Hill Notation):
C60H114NO11P
CAS Number:
Molecular Weight:
1056.52
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (857134P-5mg)

manufacturer/tradename

Avanti Research - A Croda Brand 857134P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(OC[C@@]([H])(O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

General description

Hemi-bis(monoacylglycero)phosphate (hemi-BMP) is an anionic lipid, comprising a glycerophosphoglycerol backbone in which three fatty acyl chains are esterified to the glycerol hydroxyls.

Application

18:1 Hemi BMP (S,R) may be used in the preparation of selective organ targeting (SORT) lipid nanoparticles (LNPs) for the selective mRNA delivery to the spleen.

Packaging

5 mL Clear Glass Sealed Ampule (857134P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy

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