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A77806

Sigma-Aldrich

4-Aminopyrazolo[3,4-d]pyrimidine

98%

Synonym(s):

1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine, 4-Amino-1H-pyrazolo[3,4-d]pyrimidine

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About This Item

Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
Molecular Weight:
135.13
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

powder

mp

>325 °C (lit.)

SMILES string

Nc1ncnc2[nH]ncc12

InChI

1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

InChI key

LHCPRYRLDOSKHK-UHFFFAOYSA-N

Application

Decreases serum cholesterol markedly in rats.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S Azhar et al.
Biochemistry, 23(20), 4533-4538 (1984-09-25)
These studies were done to examine the effect of gonadotropin on rat luteal 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity (the rate-limiting step in cholesterol biosynthesis) in ovaries of pregnant mare's serum gonadotropin (PMSG)-human chorionic gonadotropin (hCG) primed rats. Administration
M Bertolotti et al.
Journal of lipid research, 37(8), 1812-1822 (1996-08-01)
This study was performed to investigate the effects of 17 alpha-ethinyl estradiol, a potent hypocholesterolemic agent at pharmacological doses, on cholesterol balance in the liver and extrahepatic tissues of the rat in vivo. Female Sprague-Dawley rats were treated with 17
R F Aten et al.
Endocrinology, 135(2), 533-539 (1994-08-01)
Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We previously showed that ovarian vitamin
S Wu-Pong et al.
The Journal of investigative dermatology, 102(5), 799-802 (1994-05-01)
Barrier perturbation stimulates epidermal cholesterol synthesis, which plays an important role in restoring barrier function. In the present study, we examined whether changes in serum cholesterol levels or nutrition regulate epidermal cholesterol synthesis in hairless mice. Serum cholesterol levels were
J F Goodrum
Journal of neurochemistry, 60(4), 1564-1566 (1993-04-01)
Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration, apparently via a lipoprotein-mediated process. Because at least some serum components have access to the endoneurium of injured

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