937185

Polysuccinimide

≥95%, average M_w 60000

• Synonym(s): PSI
• Linear Formula: (C₄H₃NO₂)_n
• CAS Number: 31586-29-5
• UNSPSC Code: 12352142
• NACRES: NA.21

Properties

• Agency: suitable for controlled release
• Quality Level: 100
• Assay: ≥95%
• form: powder or chunks
• mol wt: average M_w 60000
• color: white to light brown
• application(s): advanced drug delivery; agriculture; cosmetics

Description

General description

Polysuccinimide (PSI), commonly synthesized through thermal polymerization, is a polyimide precursor for the production of such biocompatible and degradable polymers namely polyaspartic acid and various polyaspartamides. Polyaspartic acid is produced by hydrolysis of PSI under alkaline condition while polyaspartamide is produced by ring opening of PSI using a nucleophilic reagent. The presence of amide linkages in these polymers gives them peptide-like structures which is prone to hydrolysis and subsequent degradation. These derivatives could be potential substitutes for different polyamino acids in many medical applications.

Application

Polysuccinimide (PSI) has been used for a variety of applications including:

• As a nanocarrier or microcarrier delivery vehicle in pharmaceutical, cosmetic, and agriculture (agrochemical) fields
• As electrospun fibers, films, meshes or mats for wound healing applications
• As nanofibers for electronic and biosensor applications
• As a sustainable and environmentally friendly alternative to non-degradable polymers

Features and Benefits

• Biodegradable by hydrolysis allowing for sustained and controlled delivery
• High swelling ratio with superabsorbent properties
• Water soluble
• Peptide-like and biocompatible

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable