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492620

Sigma-Aldrich

Formaldehyde-d2 solution

~20 wt. % in D2O, 98 atom % D

Synonym(s):

Deuterated formaldehyde, Formalin-d2

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About This Item

Linear Formula:
DCDO
CAS Number:
1664-98-8
Molecular Weight:
32.04
MDL number:
MFCD00144373
UNSPSC Code:
12352501
PubChem Substance ID:
24872765
NACRES:
NA.12

isotopic purity

98 atom % D

Quality Level

200

concentration

~20 wt. % in D2O

technique(s)

protein expression: suitable

mass shift

M+2

SMILES string

[2H]C([2H])=O

InChI

1S/CH2O/c1-2/h1H2/i1D2

InChI key

WSFSSNUMVMOOMR-DICFDUPASA-N

General description

Formaldehyde-d2, isotopically labeled solution of formaldehyde.

Application

Formaldehyde-d2 solution is used in the synthesis of dimethylated peptides. It is also used in quantification of antigens in vaccine products.
Stable Isotope methyl labeling has led to quantification of antigens in influenza vaccine. It is also used in global antigen quantification of different types of protein-based vaccine and manufacturing intermediates.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MBBD0045
MBBC6715
MBBC3932
MBBC0031V
MBBB6203V

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Jue-Liang Hsu et al.
Analytical chemistry, 75(24), 6843-6852 (2003-12-13)
In this paper, we report a novel, stable-isotope labeling strategy for quantitative proteomics that uses a simple reagent, formaldehyde, to globally label the N-terminus and epsilon-amino group of Lys through reductive amination. This labeling strategy produces peaks differing by 28
Chunli Wang et al.
Scientific reports, 6, 22645-22645 (2016-03-05)
Proteolysis is a major form of post translational modification which occurs when a protease cleaves peptide bonds in a target protein to modify its activity. Tracking protease substrates is indispensable for understanding its cellular functions. However, it is difficult to
Kevin Colizza et al.
Journal of the American Society for Mass Spectrometry, 29(4), 675-684 (2018-01-27)
Our efforts to lower the detection limits of hexamethylene triperoxide diamine (HMTD) have uncovered previously unreported gas-phase reactions of primary and secondary amines with one of the six methylene carbons. The reaction occurs primarily in the atmospheric pressure chemical ionization
Michelle D Gonsalves et al.
Xenobiotica; the fate of foreign compounds in biological systems, 51(4), 394-403 (2021-01-14)
Triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) are prominent explosive threats. Mitigation of peroxide explosives is a priority among the law enforcement community, with canine (K9) units being trained to recognise the scent of peroxide explosives. Herein, the metabolism
Enrico S Atorino et al.
Nature communications, 11(1), 903-903 (2020-02-16)
Centrosomes are essential organelles with functions in microtubule organization that duplicate once per cell cycle. The first step of centrosome duplication is the daughter centriole formation followed by the pericentriolar material recruitment to this centriole. This maturation step was termed
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