PDE4B
phosphodiesterase 4B, cAMP-specific
Synonyms:
DPDE4, PDE4B5, PDEIVB
Species:
Human PDE4B (5142), Mouse Pde4b (18578), Rat Pde4b (24626), Domestic Rabbit PDE4B (100355058), naked mole-rat Pde4b (101703441), domestic guinea pig Pde4b (100720296), cow PDE4B (100124505), sheep PDE4B (101111757), chicken PDE4B (424700), Horse PDE4B (100053961) ...More
UniProtKB ID:
Gene ID:
- Human(5142) Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(18578) phosphodiesterase 4B, cAMP specific
- Rat(24626) phosphodiesterase 4B, cAMP specific
- Domestic Rabbit(100355058) phosphodiesterase 4B, cAMP-specific
- naked mole-rat(101703441) phosphodiesterase 4B, cAMP-specific
- domestic guinea pig(100720296) phosphodiesterase 4B, cAMP-specific
- cow(100124505) phosphodiesterase 4B, cAMP-specific
- sheep(101111757) phosphodiesterase 4B, cAMP-specific
- chicken(424700) phosphodiesterase 4B, cAMP-specific
- Horse(100053961) phosphodiesterase 4B, cAMP-specific
- domestic cat(101081316) phosphodiesterase 4B, cAMP-specific
- dog(479540) phosphodiesterase 4B, cAMP-specific
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Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PDE4B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
western blot
Anti-PDE4B Antibody, clone 1E9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PDE4B (305-end), active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
PDE4B2 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
rat
PDE4B1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
rat