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Merck

LIMS1

LIM and senescent cell antigen-like domains 1

Synonyms:
PINCH, PINCH-1, PINCH1
Species:
Human LIMS1 (3987), Mouse Lims1 (110829), Rat Lims1 (499443), domestic guinea pig Lims1 (100735007), naked mole-rat Lims1 (101696476), sheep LIMS1 (101116555), Zebrafish lims1 (554019), chicken LIMS1 (414880), dog LIMS1 (474540), Horse LIMS1 (100060267) ...More
UniProtKB ID:
P48059, B2RAJ4, B7Z483, B7Z7R3, B7Z907, Q53TE0, Q9BS44
Gene ID:
  • Human(3987) Summary: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(110829) LIM and senescent cell antigen-like domains 1
  • Rat(499443) LIM and senescent cell antigen-like domains 1
  • domestic guinea pig(100735007) LIM and senescent cell antigen-like domains 1
  • naked mole-rat(101696476) LIM and senescent cell antigen-like domains 1
  • sheep(101116555) LIM and senescent cell antigen-like domains 1
  • Zebrafish(554019) LIM and senescent cell antigen-like domains 1
  • chicken(414880) LIM and senescent cell antigen-like domains 1
  • dog(474540) LIM and senescent cell antigen-like domains 1
  • Horse(100060267) LIM and senescent cell antigen-like domains 1
  • cow(540281) LIM and senescent cell antigen-like domains 1
  • domestic cat(101094258) LIM and senescent cell antigen-like domains 1

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA058455
Anti-LIMS1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
P8996
Monoclonal Anti-PINCH-1 antibody produced in mouse, clone PINCH-C58, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
bovine, canine, hamster, human, monkey, mouse, rat
Application
ELISA
immunoprecipitation (IP)
western blot