58530AST
CHIRALPAK® CBH HPLC Column
5 μm particle size, L × I.D. 10 cm × 2.1 mm
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Recommended Products
material
stainless steel column
Quality Level
product line
CHIRALPAK®
packaging
pkg of 1 ea
manufacturer/tradename
CHIRALPAK®
parameter
137 bar pressure (2000 psi)
20-30 °C temperature
40 °C max. temp.
technique(s)
HPLC: suitable
L × I.D.
10 cm × 2.1 mm
matrix
fully porous particle
matrix active group
cellobiohydrolase phase
particle size
5 μm
operating pH
2-8
separation technique
chiral
Looking for similar products? Visit Product Comparison Guide
General description
Hermansson described the use of natural proteins immobilized onto a silica support for chiral separations in 1983 (1). Proteins contain a large number of chiral centers of one configuration, and many other sites that contribute to the general retention process. Used primarily for the separation enantiomers of basic compounds, CHIRALPAK CBH phase has cellobiohydrolase as the chiral selector immobilized on spherical 5 μm silica particles. Used in reversed-phase mode, retention and enantioselectivity is regulated by changes of pH, buffer concentration and organic modifier. The mobile phases are mixtures of phosphate or acetate buffers and organic solvents such as 2-propanol or acetonitrile. The column is preferably used for the separation of enantiomers of basic drugs, particularly compounds containing one or more nitrogen atoms along with one or more hydrogen-bonding groups (alcohol, phenol, carbonyl, amide, ether, ester, etc.).
Features:
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Features:
- Direct reversed phase resolution of chiral molecules
- Stable with a variety of organic modifiers
- Available in analytical and semi-preparative sizes
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Legal Information
CHIRALPAK is a registered trademark of Daicel Corp.
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Sorry, we don't have COAs for this product available online at this time.
If you need assistance, please contact Customer Support.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service