SML1162

5-Fluoro-1-propargyl-uracil

≥98% (HPLC)

• Synonym(s): 1-Propargyl-5-fluorouracil, 5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
• Empirical Formula (Hill Notation): C₇H₅FN₂O₂
• CAS Number: 69849-33-8
• Molecular Weight: 168.13
• MDL number: MFCD18364451
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825692
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C1C(F)=CN(CC#C)C(N1)=O
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• InChI key: GMCOGJQJFDQZCP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil iside a tumor that has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable