SML1160

CD40-TRAF6 signaling inhibitor

≥98% (HPLC)

• Synonym(s): 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one, Compound 6877002
• Empirical Formula (Hill Notation): C₁₇H₁₇NO
• CAS Number: 433249-94-6
• Molecular Weight: 251.32
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825690
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
• InChI: 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
• InChI key: WIFPLULEUNBSTE-GZTJUZNOSA-N

Description

Application

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

Biochem/physiol Actions

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.

CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable