SML0033

Itopride hydrochloride

≥98% (HPLC)

• Synonym(s): N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₂₆N₂O₄ ·HCl
• CAS Number: 122892-31-3
• Molecular Weight: 394.89
• MDL number: MFCD00881710
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825103
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥48 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
• InChI: 1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
• InChI key: ZTOUXLLIPWWHSR-UHFFFAOYSA-N

Description

General description

Itopride hydrochloride is a new prokinetic drug.

Biochem/physiol Actions

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable