SAB5600057

Anti-p38 MAPK Phospho (pT180/pY182) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM243, purified immunoglobulin

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• recombinant: expressed in HEK 293 cells
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM243, monoclonal; recombinant monoclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• technique(s): immunoblotting: 1:1000-1:2000; immunohistochemistry: 1:500-1:1000
• isotype: IgG
• NCBI accession no.: 1432
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr180/pTyr182)
• Gene Information: human ... MAPK14(1432)

Description

General description

The mitogen activated protein kinase (MAPK) gene codes for a serine/threonine protein kinase which is found to be expressed in majority of cells. The MAPK gene is mapped to human chromosome 6p21.31 and the encoded protein consists of 90 to 360 amino acids residues. MAPKs are divided into three subtypes : extracellular signal-regulated kinases (ERK), c-Jun amino-terminal kinases (JNK) and p38 MAPK (p38).

Specificity

This antibody reacts to p38 MAPK only when dual phosphorylation at Thr180 and Tyr182 is observed. There is no cross-reactivity with p38 MAPK without dual phosphorylation at Thr180 and Tyr182.

Immunogen

Synthetic phospho-peptide corresponding to human Phospho-p38 MAPK (Thr180/Tyr182)

Application

Anti-p38 MAPK Phospho (pT180/pY182) antibody, Rabbit monoclonal has been used for immunodetection.

Biochem/physiol Actions

Mitogen activated protein kinase (MAPK) participates in transdifferentiation of adipocytes in myoblast by regulating adipogenic and adipolysis metabolism. p38 MAPK is associated with various biological processes as such as cell proliferation and differentiation, cell adhesion, migration. It mediates pro-apoptotic signal during apoptosis, contributing either to cell death or survival.. p38 MAPK is known to mediate a number of metabolic pathways by controlling transcription, mRNA stability, chromatin remodelling and protein synthesis. During initial process of tumorigenesis, It acts as a tumor suppressor, while it might promote metastasis in the later stages of the same. p38 MAPK gets activated in response to growth factors, oxidative stress, proinflammatory cytokines and DNA damage.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable