Skip to Content
Merck
All Photos(4)

Key Documents

SAB4503970

Sigma-Aldrich

Anti-phospho-PLB (pSer16+Thr17) antibody produced in rabbit

affinity isolated antibody

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 6 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500

NCBI accession no.

P26678

UniProt accession no.

P26678

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PLN(5350)

General description

Phospholamban (PLN) gene codes for a small integral membrane protein. It is located on human chromosome 6q22.1. PLN is a 52-amino-acid phosphoprotein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17.

Immunogen Range: 1-50

Biochem/physiol Actions

Phospholamban (PLN) participates in calcium signalling and muscle contraction. This protein regulates the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) of cardiac myocytes. Mutations in the phospholamban (PLN) gene result in dilated cardiomyopathy (DCM) and severe heart failure.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy.
Bos J M, et al.
Journal of the American College of Cardiology, 54(3), 201-211 (2009)
Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.
Fish M, et al.
Scientific Reports, 6, 22235-22235 (2016)
Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
Smeazzetto S, et al.
Physical Chemistry Chemical Physics, 18(3), 1629-1636 (2016)
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
Haghighi K, et al.
The Journal of Clinical Investigation, 111(6), 869-876 (2003)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service