SAB1407182

Anti-EPB41L3 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Synonym(s): 4.1B, DAL-1, DAL1, FLJ37633, KIAA0987
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~96.5 kDa
• species reactivity: human
• technique(s): western blot: 1 μg/mL
• NCBI accession no.: BC006141.1
• UniProt accession no.: Q9Y2J2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EPB41L3(23136)

Description

General description

Erythrocyte membrane protein band 4.1-like 3 (EPB41L3)/protein 4.1B is expressed at high levels in the brain and neurons. Adipose tissue, kidney, testis, adrenal gland, and placenta also show high expression of EPB41L3. It is moderately expressed in the lungs and intestines. EPB41L3 gene is located on human chromosome 18p11.31. Protein 4.1B belongs to the protein 4.1 superfamily of proteins. It has an N-terminal 4.1/ezrin/radixin/moesin (FERM) domain.

Immunogen

EPB41L3 (AAH06141.1, 1 a.a. ~ 865 a.a) full-length human protein.

Sequence
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKTDSERTDTAADGETTATEELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEEKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED

Biochem/physiol Actions

Erythrocyte membrane protein band 4.1-like 3 (EPB41L3)/protein 4.1B helps in linking cellular receptors with the cytoskeleton. It possesses tumor-suppressive action. In human, overexpression of EPB41L3 gene can stimulate apoptosis in breast cancer, non-small cell lung cancer, and meningioma cells.

Physical form

Solution in phosphate buffered saline, pH 7.4

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable