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GS38

Sigma-Aldrich

GST T1-1, Recombinant Rat

Synonym(s):

AI255817: glutathione S-transferase, glutathione S-transferase, theta 1, Gstt1-1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.26

biological source

rat

Quality Level

100

recombinant

expressed in E. coli

Assay

>95% (SDS-PAGE)

form

frozen liquid

specific activity

86.6 (using spectrophotometric determination of 1,2-epoxy-3(4-nitrophenoxy)propane (ENPP) conjugation with reduced glutathione (5 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.)

mol wt

25 kDa

concentration

1.22 mg/mL

storage temp.

−70°C

Gene Information

rat ... Gstt1(14871)

Biochem/physiol Actions

Glutathione S-transferase theta 1 (Gstt1) is an enzyme that in rats is encoded by the Gstt1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Storage and Stability

The enzyme should be used by the end-user customer within 1 year of receipt.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Anna-Karin Larsson et al.
Archives of biochemistry and biophysics, 497(1-2), 28-34 (2010-03-10)
Glutathione transferase (GST) displaying enhanced activity with the cytostatic drug 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and structurally related alkylating agents was obtained by molecular evolution. Mutant libraries created by recursive recombination of cDNA coding for human and rodent Theta-class GSTs were heterologously expressed

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