A9965

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin

≥95% (HPLC), powder

• Synonym(s): Ac-YVAD-AFC
• Linear Formula: C₃₃H₃₆N₅O₁₀F₃
• Molecular Weight: 719.66
• MDL number: MFCD01318881
• UNSPSC Code: 12352209
• PubChem Substance ID: 329771064
• NACRES: NA.32

Properties

• Assay: ≥95% (HPLC)
• form: powder
• color: white
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2
• InChI: 1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1
• InChI key: GWKJISJKNKIJNP-DEQDFGQZSA-N
• Gene Information: human ... CASP1(834) , CASP4(837) ; mouse ... CASP1(12362) , CASP4(12363) ; rat ... CASP1(25166) , CASP4(114555)

Description

Amino Acid Sequence

NAc-Tyr-Val-Ala-Asp-AFC

Substrates

Membrane-permeable fluorogenic substrate for caspase 1 (ICE) and caspase 4 (TX).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves