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Key Documents

901989

Sigma-Aldrich

Tetrazine-NHS ester

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About This Item

Empirical Formula (Hill Notation):
C14H11N5O4
Molecular Weight:
313.27
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22

form

powder

availability

available only in USA

mp

171-177 °C

storage temp.

−20°C

Application

Tetrazine-NHS ester demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M-1 s-1). These have been the fastest kinetics reported for a bioorthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Pictograms

Flame

Signal Word

Danger

Hazard Statements

Hazard Classifications

Self-react. C

Storage Class Code

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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