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K-002

Supelco

Ketamine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C13H17Cl2NO
CAS Number:
1867-66-9
Molecular Weight:
274.19
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

psicótropo (Spain)

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

InChI key

VCMGMSHEPQENPE-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444)

General description

This certified solution standard is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS testing applications from forensic analysis and clinical toxicology to urine drug testing.

Ketamine is a phencyclidine type of anaesthetic drug that blocks the N-methyl-d-aspartate (NMDA) receptors present on neurons. It is also an abused drug owing to its euphoric and hallucinogenic effects. The drug is also abused at clubs, raves, or parties for its noted hallucinogenic and dissociative properties and is prescribed by some doctors as an off-label treatment for depression.

Application

The certified reference solution (CRM) in solution can also be used as follows:
  • Development of a chiral liquid chromatography-tandem mass spectrometric (LC-MS/MS) method to quantify enantiomers of ketamine and norketamine in plasma, brain, and cerebrospinal fluid samples obtained from mouse
  • Multi-residue and non-destructive analysis of ketamine, methamphetamine, heroin, and cocaine by a near-infrared spectroscopic (NIR) method in seized drug samples
  • Combined detection and estimation of ketamine, free methamphetamine, pethidine, and tramadol in human urine samples using dispersive liquid-liquid microextraction (DLLME) and gas chromatography-mass spectrometry (GC-MS)
  • Electrochemical determination of ketamine in human urine samples using a metal-organic framework/graphene nanocomposite (MOFs@G) modified screen-printed electrode (SPE) after the UV polymerization of molecularly imprinted membranes on its surface
  • Simultaneous analysis of ketamine, GHB, norketamine, phenobarbital, thiopental, zolpidem, zopiclone, and phenytoin in human urine samples by a LC-MS/MS procedure following a four-step liquid-liquid extraction of the samples

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

D-046

Dehydronorketamine hydrochloride solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

K-003

Ketamine-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-036

(±)-Norketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-037

(±)-Norketamine-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-144

N-Ethyldeschloroketamine hydrochloride solution, 1 mg/mL in methanol ((as free base)), certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ketamine impurity A

Xylazine ≥99%

Sigma-Aldrich

X1126

Xylazine

Ege T Kavalali et al.
The American journal of psychiatry, 169(11), 1150-1156 (2013-03-28)
Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major depressive disorder, with effects lasting up to 2 weeks. Despite enthusiasm about
Going beyond anesthesia in space exploration missions: emergency medicine and emergency medical care.
Jochen Hinkelbein et al.
Aviation, space, and environmental medicine, 84(7), 747-747 (2013-07-17)
Ketamine infusion as a treatment for major depressive disorder: a new role for anesthesiologists?
Joshua D Dilley et al.
Middle East journal of anaesthesiology, 21(6), 871-873 (2013-05-03)
Ketamine-medetomidine regimen for chemical immobilisation of free-ranging chimpanzees (Pan troglodytes schweinfurthii) in Uganda.
D Hyeroba et al.
The Veterinary record, 172(18), 475-475 (2013-04-02)
Kaixin Fu et al.
Biosensors & bioelectronics, 143, 111636-111636 (2019-09-03)
Ketamine is one of the most widely abused drugs in the world and poses a serious threat to human health and social stability; therefore, the ability to accurately monitor the substance in real-time is necessary. However, several problems still exists
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