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780201C

Avanti

18:1 PE MCC

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C53H90N2NaO11P
CAS Number:
384847-49-8
Molecular Weight:
985.25
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (780201C-25mg)

manufacturer/tradename

Avanti Polar Lipids 780201C

concentration

10 mg/mL (780201C-25mg)

shipped in

dry ice

storage temp.

−20°C

General description

18:1 PE MCC (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide]) lipid comprising of phosphoethanolamine linked to two oleic acid via its phosphate group and to a maleimide group via its amino group. It is a maleimide-functionalized thiol-reactive lipid.

Application

18:1 PE MCC 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] has been used:
  • in liposome preparation for cysteine coupling studies
  • in nanodisc impregnation for ras sarcoma protein (K-RAS4B) tethering
  • in liposome preparation for single molecule imaging

Packaging

5 mL Clear Glass Sealed Ampule (780201C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Liposome-based assays to study membrane-associated protein networks
Methods in Enzymology, 534, 223-243 (2014)
Walter Huynh et al.
The Journal of cell biology, 216(10), 3051-3060 (2017-09-09)
Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored

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