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54965

Sigma-Aldrich

(±)-Sodium 3-hydroxybutyrate

≥99.0% (NT)

Synonym(s):

(±)-3-Hydroxybutyric acid sodium salt

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About This Item

Linear Formula:
CH3CH(OH)CH2COONa
CAS Number:
150-83-4
Molecular Weight:
126.09
Beilstein:
4824866
EC Number:
205-774-5
MDL number:
MFCD00016716
UNSPSC Code:
12352100
PubChem Substance ID:
57651496
NACRES:
NA.22

Quality Level

200

Assay

≥99.0% (NT)

mp

167-170 °C

SMILES string

[Na+].CC(O)CC([O-])=O

InChI

1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

InChI key

NBPUSGBJDWCHKC-UHFFFAOYSA-M

Application

(±)-Sodium 3-hydroxybutyrate has been used in a study to understand the effect of butyrate on fibroblast growth factor 21 (FGF21), which is involved in fatty acid ß-oxidation in liver. It may be used in the preparation of poly(3-hydroxybutyrate).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Novel synthesis of poly (3-hydroxybutyrate).
Juzwa M and Jedli?ski Z.
Macromolecules, 39(13), 4627-4630 (2006)
Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3.
Li H, et al.
Diabetes, 61(4), 797-806 (2012)
Shengying Pan et al.
Behavioural pharmacology, 31(4), 322-332 (2020-01-03)
β-hydroxybutyrate, a ketone body metabolite, has been shown to suppress depression-like behavior in rodents. In this study, we examined its antidepressive property in acute and chronic administration modes in mice by using forced swim test and tail suspension test. Results
Nikolaj Rittig et al.
Shock (Augusta, Ga.), 44(1), 32-35 (2015-04-22)
Endotoxin administrations are used in experimental models of inflammatory disease. Short-term endotoxin tolerance in response to repeated endotoxin exposure is well known, but the duration of endotoxin tolerance in humans remains unknown. The main purpose of this study was to
Stephanie Lilja et al.
Oxidative medicine and cellular longevity, 2020, 4793125-4793125 (2020-11-06)
We investigated different bioactive compounds including epigallocatechin gallate (EGCG), anthocyanidin, resveratrol, phloretin, spermidine, butyrate, and β-hydroxybutyrate with regard to their effect on SIRT3 via NRF2 and modulation of the proinflammatory senescence-associated secretory phenotype (SASP) in senescence induced 3T3-L1 preadipocytes. For
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