162957

6-Hydroxydopamine hydrobromide

95% (HPLC), powder, neurotoxin 

• Synonym(s): 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
• Linear Formula: (HO)₃C₆H₂CH₂CH₂NH₂ · HBr
• CAS Number: 636-00-0
• Molecular Weight: 250.09
• Beilstein: 3713280
• EC Number: 211-247-0
• MDL number: MFCD00012894
• UNSPSC Code: 12352116
• PubChem Substance ID: 329751177
• NACRES: NA.77

Properties

• Product Name: 6-Hydroxydopamine hydrobromide, 95%
• Quality Level: 100
• Assay: 95%
• form: powder
• mp: 216-220 °C (lit.)
• storage temp.: −20°C
• SMILES string: Br.NCCc1cc(O)c(O)cc1O
• InChI: 1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• InChI key: MLACDGUOKDOLGC-UHFFFAOYSA-N

Description

General description

Solutions should be freshly prepared and protected from exposure to light.

Application

6-Hydroxydopamine hydrobromide has been used:

• to induce Parkinson′s disease (PD) in mouse models to study the effects of tubastatin A (TBA) on nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) activation and cell injury in SH-SY5Y cells
• to induce pharmacological ablation of the sympathetic nerves to study the effect of hepatic sympathetic nerve activity (SNA) on hepatic steatosis during diet-induced obesity in mice
• to induce oxidative stress in mesencephalic cells to study its effect on p75^NTR signaling in neuronal cells of the ventral mesencephalon

Biochem/physiol Actions

6-Hydroxydopamine hydrobromide (6-OHDA) is a neurotoxin that elicits oxidative damage and destroys catecholaminergic or sympathetic terminals. It is commonly used to induce Parkinson′s disease in the experimental model. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves