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Merck
  • Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient.

Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient.

The Journal of infectious diseases (2013-12-07)
Anthony R Flores, Pranoti Sahasrabhojane, Miguel Saldaña, Jessica Galloway-Peña, Randall J Olsen, James M Musser, Samuel A Shelburne
摘要

Invasive group A streptococcal (GAS) strains often have genetic differences compared to GAS strains from nonsterile sites. Invasive, "hypervirulent" GAS strains can arise from a noninvasive progenitor following subcutaneous inoculation in mice, but such emergence has been rarely characterized in humans. We used whole genome analyses of multiple GAS isolates from the same patient to document the molecular basis for emergence of a GAS strain with an invasive phenotype during human infection. In contrast to previous theories, we found that elimination of production of the cysteine protease SpeB was not necessary for emergence of GAS with an invasive, "hypervirulent" phenotype.

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Sigma-Aldrich
头孢曲松 二钠盐 半(七水合物), third-generation cephalosporin antibiotic
USP
头孢曲松 二钠盐 半(七水合物), United States Pharmacopeia (USP) Reference Standard
Supelco
头孢曲松钠, Pharmaceutical Secondary Standard; Certified Reference Material
头孢曲松 二钠盐 半(七水合物), European Pharmacopoeia (EP) Reference Standard