推荐产品
等級
pharmaceutical primary standard
API 家族
diclofenac
製造商／商標名
USP
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChI 密鑰
KPHWPUGNDIVLNH-UHFFFAOYSA-M
基因資訊
human ... PTGS1(5742) , PTGS2(5743)
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一般說明
双氯芬酸钠是一种非甾体抗炎药（NSAID）双氯芬酸的钠盐。它通过抑制环氧合酶活性来防止与疼痛、炎症和发烧有关的前列腺素的合成。
本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。
應用
双氯芬酸钠USP 参考标准品适用于指定USP 药典质量测试和分析。
还用于制备酸级标准（acid stage standard）、标准、标准储备、敏感性和系统适用性溶液，用于根据美国药典 (USP) 的以下专论，通过液相色谱和紫外检测器进行检测、杂质分析、鉴定和性能测试：
还用于制备酸级标准（acid stage standard）、标准、标准储备、敏感性和系统适用性溶液，用于根据美国药典 (USP) 的以下专论，通过液相色谱和紫外检测器进行检测、杂质分析、鉴定和性能测试：
- 双氯芬酸钠
- 双氯芬酸钠延迟释放片
- 双氯芬酸钠缓释片
- 双氯芬酸钠外用溶液
- 双氯芬酸钠和迷索前列醇延迟释放片
生化／生理作用
标准NSAID和环加氧酶（COX）抑制剂。主要代谢物是4′-羟基二苯甲酸和5′-羟基二氯芬酸。已被用作CYP2C9的选择性底物。
分析報告
这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。
其他說明
可能适用相应的销售限制。
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Adaptation of a color reaction for spectrophotometric determination of diclofenac sodium and piroxicam in pure form and in pharmaceutical formulations
El-Didamony, AM and Amin, AS
Analytical Letters, 37(6), 1151-1162 (2004)
R N Brogden et al.
Drugs, 20(1), 24-48 (1980-07-01)
Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal, anti-inflammatory, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions, and in the treatment of pain resulting from minor surgery, trauma and dysmenorrhoea. Published
D Aygün et al.
Histology and histopathology, 27(4), 417-436 (2012-03-01)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment
Paul L McCormack et al.
Drugs, 68(1), 123-130 (2007-12-18)
*A new formulation of the nonselective NSAID diclofenac sodium suitable for intravenous bolus injection has been developed using hydroxypropyl beta-cyclodextrin as a solubility enhancer (HPbetaCD diclofenac). * HPbetaCD diclofenac intravenous bolus injection was shown to be bioequivalent to the existing
R E Small
Clinical pharmacy, 8(8), 545-558 (1989-08-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of diclofenac sodium are reviewed. Diclofenac, the first nonsteroidal anti-inflammatory agent (NSAID) to be approved that is a phenylacetic acid derivative, competes with arachidonic acid for binding to cyclo-oxygenase, resulting in
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