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Merck
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文件

1029002

USP

盐酸阿米替林 盐酸盐

United States Pharmacopeia (USP) Reference Standard

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About This Item

经验公式（希尔记法）:
C20H23N · HCl
CAS号:
549-18-8
分子量:
313.86
MDL號碼:
MFCD00012537
分類程式碼代碼:
41116107
PubChem物質ID:
329749005
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

amitriptyline

製造商／商標名

USP

應用

pharmaceutical (small molecule)

格式

neat

SMILES 字串

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI 密鑰

KFYRPLNVJVHZGT-UHFFFAOYSA-N

基因資訊

human ... SLC6A2(6530) , SLC6A4(6532)

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相关类别

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Amitriptyline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amitriptyline Hydrochloride Tablets
  • Chlordiazepoxide and Amitriptyline Hydrochloride Tablets
  • Cyclobenzaprine Hydrochloride Extended-Release Capsules
  • Perphenazine and Amitriptyline Hydrochloride Tablets

生化／生理作用

三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

相關產品

产品编号
说明
价格

D1000000

二苯并环庚酮, European Pharmacopoeia (EP) Reference Standard

Y0000563

盐酸阿米替林 盐酸盐, European Pharmacopoeia (EP) Reference Standard

1029013

二苯并软木酮, United States Pharmacopeia (USP) Reference Standard

1029024

Amitriptyline Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1776

阿米替林相关化合物B, Pharmaceutical Secondary Standard; Certified Reference Material

BP016

盐酸阿米替林 盐酸盐, British Pharmacopoeia (BP) Reference Standard

BP858

二苯并环庚酮, British Pharmacopoeia (BP) Reference Standard

PHR2836

Amitriptyline Related Compound A, certified reference material, pharmaceutical secondary standard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Ming Yang et al.
Aquatic toxicology (Amsterdam, Netherlands), 151, 68-76 (2014-01-23)
Amitriptyline is a tricyclic antidepressant used for decades. It is present at low detectable concentrations in the aquatic environment, but relative few studies have focused on its ecotoxicological effects on non-target aquatic animals. The present study conducted an acute toxicity
Katja Kovacic et al.
The Journal of pediatrics, 164(5), 1104-1109 (2014-03-13)
To compare children with primary, chronic idiopathic nausea to those with secondary nausea associated with functional abdominal pain. Retrospective chart review of 45 children with a primary complaint of chronic nausea several times per week. Comparisons were made to prospectively
Mariola Herbet et al.
Acta poloniae pharmaceutica, 70(5), 913-917 (2013-10-24)
The aim of the present study was to assess the impact of combined therapy with rosuvastatin (10 mg/kg) and amitriptyline (10 mg/kg) on oxidation-reduction status in the blood of rats. After 2-week application of drugs alone or their combination, the
Jennifer S Gewandter et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 22(7), 1807-1814 (2014-02-18)
Chemotherapy-induced peripheral neuropathy (CIPN) occurs in as high as 70% of patients receiving certain types of chemotherapy agents. The FDA has yet to approve a therapy for CIPN. The aim of this multicenter, phase III, randomized, double-blind, placebo-controlled trial was
Treatment of epidermolysis bullosa pruriginosa using systemic and topical agents.
Aaron R Mangold et al.
Journal of the American Academy of Dermatology, 70(6), e136-e137 (2014-05-17)
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