PHL86246

Conessine

phyproof^® Reference Substance

• 别名: N,18-Dihydrotrimethylconkurchine, (3β)-N,N-dimethyl-con-5-enin-3-amine, Conessin, NSC 119994, Neriine, Roquessine, Wrightine
• 经验公式（希尔记法）: C₂₄H₄₀N₂
• CAS号: 546-06-5
• 分子量: 356.59
• MDL號碼: MFCD00016752
• 分類程式碼代碼: 12352103
• NACRES: NA.24

属性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥90.0% (HPLC)
• 製造商／商標名: PhytoLab
• 應用: food and beverages; pharmaceutical
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
• InChI: 1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
• InChI 密鑰: GPLGAQQQNWMVMM-MYAJQUOBSA-N

说明

一般說明

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化／生理作用

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H₃ receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H₃ over H₄ and does not bind to H₁ or H₂ receptors. The molecule also binds to the human α₂C₄ adrenergic receptor (pKi = 7.98).

H3 receptor antagonist

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable