推荐产品
product name
Astec® CHIROBIOTIC® T 手性 HPLC 色谱柱, 5 μm particle size, L × I.D. 25 cm × 10 mm
材料
stainless steel column
品質等級
agency
suitable for USP L63
描述
HPLC column
產品線
Astec®
包裝
pkg of 1 ea
製造商／商標名
Astec®
參數
0-45 °C temperature
241 bar pressure (3500 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
25 cm × 10 mm
基質
High-purity silica gel particle platform
fully porous particle
基質活性組
teicoplanin glycopeptide phase
粒徑
5 μm
孔徑
100 Å
工作pH值範圍
3.8-6.8
分離技術
chiral
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相关类别
一般說明
CHIROBIOTIC® T和T2具有替考拉宁作为手性选择剂。它们对许多类别的分子可提供独特的选择性，特别是未衍生化的α, β, γ以及环氨基酸、N-衍生氨基酸、羟基-羧基酸，酸性化合物包括羧基酸及酚、小肽、中性芳香族分析物及环状芳香族和脂肪族胺。通常在手性的冠醚或配体交换型CSP上获得的分离也可能发生在CHIROBIOTIC®T和T2上，但是是在大为简单的移动相如水-乙醇中。此外，所有已知的β-阻滞剂（氨醇）以及二氢香豆素都已被分解。CHIROBIOTIC® T和T2在它们的键化学和支持颗粒的孔径上存在差别，分别赋予了它们不同的选择和制备能力。
CHIROBIOTIC FAQ
CHIROBIOTIC 参考书目
Chiral产品文献
- 键合相：替考拉宁
- 操作pH范围：3.8 - 6.8
- 粒子直径：5、10或16 μm
- 孔径：100 Å (CHIROBIOTIC® T)或200 Å (CHIROBIOTIC® T2)
CHIROBIOTIC FAQ
CHIROBIOTIC 参考书目
Chiral产品文献
應用
- Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.: This study outlines the development of a chiral LC-MS/MS method utilizing the Astec® CHIROBIOTIC® T Chiral HPLC Column for detecting salbutamol enantiomers in urine, showcasing its application in doping control and analytical chemistry. The research demonstrates the column′s capability for precise and selective measurement of chiral molecules in complex biological matrices (Chan et al., 2016).
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: Highlighting the versatility of Astec® CHIROBIOTIC® T Chiral HPLC Column, this paper details the enantioseparation of cyclic amino acids critical for the development of new pharmaceuticals and biochemical studies. The column′s effectiveness in resolving complex chiral acids reinforces its importance in pharmaceutical research and chiral chemical analysis (Berkecz et al., 2009).
法律資訊
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Felikss Mutulis et al.
Bioorganic & medicinal chemistry, 15(17), 5787-5810 (2007-07-10)
Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff
Balázs Visegrády et al.
Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out
Mohamed M Hefnawy et al.
Talanta, 61(5), 667-673 (2008-10-31)
A new analytical method for the separation and determination of R-(-)- and S-(+)- baclofen enantiomers in human plasma by high-performance liquid chromatography (HPLC) with UV detection was developed. Enantioselective resolution of the baclofen enantiomers was achieved by using teicoplanin macrocyclic
Zahid Ali et al.
Journal of chromatography. A, 1052(1-2), 199-204 (2004-11-06)
The solvation parameter model is used to characterize the retention properties of a 3-aminopropylsiloxane-bonded (Alltima amino), three 3-cyanopropylsiloxane-bonded (Ultrasphere CN, Ultremex-CN and Zorbax SB-CN), a spacer bonded propanediol (LiChrospher DIOL) and a multifunctional macrocyclic glycopeptide (Chirobiotic T) silica-based stationary phases
M Sanghvi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 933, 37-43 (2013-07-23)
Due to the lack of sensitivity in current methods for the determination of fenoterol (Fen), a rapid LC-MS/MS method was developed for the determination of (R,R')-Fen and (R,R';S,S')-Fen in plasma and urine. The method was fully validated and was linear
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