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product name
扎格雷酸 A 三钠盐, ≥95% (HPLC), microbial
生物源
microbial
品質等級
化驗
≥95% (HPLC)
形狀
lyophilized powder
溶解度
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
運輸包裝
wet ice
儲存溫度
−20°C
應用
萨拉哥(Zaragozic)酸 A 三钠盐可用作:
- 人类胚胎肾细胞的无血清培养基成分,在伤口刮擦测定中检测其对伤口愈合的作用
- 抑制剂,在基质细胞中抑制法尼基二磷酸法尼基转移酶1(FDFT1)或角鲨烯合成酶
- T细胞中的胆固醇合成抑制剂
生化/生理作用
哺乳动物,真菌和酿酒酵母角鲨烯合成酶的体内和体外有效抑制剂。角鲨烯合成酶是固醇合成中的第一个关键酶,催化焦磷酸法尼基还原缩合形成角鲨烯。作为角鲨烯合成酶抑制剂,扎格雷酸在灵长类动物中产生较低的血浆胆固醇水平。用扎格雷酸 A 处理大鼠导致肝脏低密度脂蛋白 (LDL) 受体 mRNA 水平升高。
法律資訊
根据 Merck & Co.,Inc.,Kenilworth,NJ 限制性授权许可生产和销售。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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