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Z103

Sigma-Aldrich

Zolpidem

≥98% (HPLC), solid, benzodiazepine receptor agonist

别名:

N,N,6-Trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide

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About This Item

经验公式（希尔记法）:
C19H21N3O
CAS号:
82626-48-0
分子量:
307.39
MDL號碼:
MFCD00153885
分類程式碼代碼:
12352200
PubChem物質ID:
24902172
NACRES:
NA.77

product name

Zolpidem, ≥98% (HPLC), solid

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

藥物控制

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

顏色

white

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
DMSO: >10 mg/mL
ethanol: 50 mg/mL
methanol: 50 mg/mL
H2O: insoluble
dilute aqueous base: insoluble

起源

Sanofi Aventis

SMILES 字串

CC1=CN2C(C=C1)=NC(C3=CC=C(C)C=C3)=C2CC(N(C)C)=O

InChI

1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

InChI 密鑰

ZAFYATHCZYHLPB-UHFFFAOYSA-N

基因資訊

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRG2(2566)
rat ... Gabra1(29705) , Gabra2(29706) , Gabra5(29707) , Tspo(24230)

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生化／生理作用

Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation markEnvironment
GHS07,GHS09

訊號詞

Warning

危險聲明

H302,H336,H411

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Ji-Yeong Byeon et al.
Archives of pharmacal research, 41(8), 861-866 (2018-08-18)
Zolpidem is indicated for the short-term treatment of insomnia and it is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C19, CYP1A2, and CYP2C9. Therefore, we evaluated the effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of zolpidem
Sara C Mednick et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4494-4504 (2013-03-08)
An important function of sleep is the consolidation of memories, and features of sleep, such as rapid eye movement (REM) or sleep spindles, have been shown to correlate with improvements in discrete memory domains. Because of the methodological difficulties in
Hsin-I Shih et al.
Medicine, 94(17), e809-e809 (2015-05-02)
We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD).A retrospective population-based nested case-control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A
Eunmi Kim et al.
Forensic science international, 269, 50-55 (2016-11-21)
The southern area of South Korea consists of three parts; Busan, Ulsan and Gyeongsangnam-do. Busan Institute of National Forensic Service (NFS) performed about 50,000 cases throughout the southern area in 2014, occupying over 15% of total cases covered by NFS.
Franck Da-Silva et al.
Journal of pharmaceutical sciences, 107(7), 1957-1972 (2018-03-11)
The objective was to compare, with the same data set, the predictive performance of 3 in vitro assays of hepatic clearance (CL), namely, micropatterned cocultures (also referring to HepatoPac®) and suspension as well as monolayer hepatocytes to define which assay is
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