W2394

Anti-WIPI-1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 别名: Anti-ATG18, Anti-WD repeat domain phosphoinositide interacting 1, Anti-WD40 repeat protein Interacting with phosphoInositides of 49kDa, Anti-WIPI-1 alpha, Anti-WIPI49
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~49 kDa
• 物種活性: human, rat, mouse
• 濃度: ~1.0 mg/mL
• 技術: immunoprecipitation (IP): 5-10 μg using lysates of mouse 3T3 or at NRK cells; western blot: 2.5-5.0 μg/mL using whole extract of G-361 cells
• UniProt登錄號: Q5MNZ9
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... WIPI1(55062) ; mouse ... Wipi1(52639) ; rat ... Wipi1(303630)

说明

一般說明

WIPI-1, the mammalian orthologue of Atg18 in S. cerevisiae and A. thaliana, is a member of the WIPI subfamily of WD-repeat proteins. It has a 7-bladed propeller structure and contains a conserved motif for interaction with phospholipids. WIPI-1 is ubiquitously expressed in normal human tissues with highest levels in skeletal muscle, heart and testis. It is aberrantly expressed in human cancer.

免疫原

synthetic peptide corresponding to amino acids 406-421 of human WIPI-1, conjugated to KLH. The corresponding sequence is identical in mouse and rat.

應用

Anti-WIPI-1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

生化／生理作用

WIPI-1 has essential biological functions including signal transduction, transcription regulation and apoptosis. WD-repeat proteins regulate the assembly of multiprotein complexes by presenting a β-propeller platform for simultaneous and reversible protein-protein interactions. WIPI-1 is linked to starvation-induced autophagy.

外觀

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)