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Merck

V7881

Sigma-Aldrich

Monoclonal Anti-Vitronectin antibody produced in mouse

clone VIT-2, ascites fluid

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

ascites fluid

抗體產品種類

primary antibodies

無性繁殖

VIT-2, monoclonal

分子量

antigen 65-75 kDa

包含

15 mM sodium azide

物種活性

human

技術

indirect ELISA: suitable
indirect immunofluorescence: suitable using human cultured fibroblasts
microarray: suitable
western blot: 1:2,500 using a denatured and reduced preparation of purified human plasma vitronectin

同型

IgM

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... VTN(7448)

一般說明

Monoclonal Anti-Vitronectin (mouse IgM isotype) is derived from the VIT-2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human plasma vitronectin. Vitronectin is also referred as serum-spreading factor, S-protein of complement or epibolin. This monomeric acidic protein is one of the major multifunctional cell-adhesive glycoproteins in mammalian plasma and serum. This protein is usually seen as a mixture of 75 kDa and 65 kDa polypeptides. Human plasma and serum contain 0.1-0.4 mg/ml of vitronectin which is synthesized in the liver. It is also present in amniotic fluid and urine.

特異性

By immunoblotting, the product shows no cross-reactivity with fibronectin, laminin, merosin, collagen type IV or chondroitin sulfate types A, B and C.

免疫原

human plasma vitronectin

應用

Monoclonal Anti-Vitronectin antibody produced in mouse has been used in:
  • immunocytochemisry
  • western blotting
  • immunoprecipitation
  • immunofluorescence
  • enzyme-linked immunosorbent assay (ELISA)

生化/生理作用

Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b-9 complex. Vitronectin protects thrombin from inactivation by antithrombin III in the presence of heparin, binds and stabilizes the activity of plasminogen activator inhibitor and mediates many other physiological functions.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mengzhu Cheng et al.
Ecotoxicology and environmental safety, 158, 94-99 (2018-04-17)
The pollution of rare earth elements (REEs) in ecosystem is becoming more and more serious, so it is urgent to establish methods for monitoring the pollution of REEs. Monitoring environmental pollution via the response of plants to pollutants has become
M Delannet et al.
Development (Cambridge, England), 120(9), 2687-2702 (1994-09-01)
To identify potentially important extracellular matrix adhesive molecules in neural crest cell migration, the possible role of vitronectin and its corresponding integrin receptors was examined in the adhesion and migration of avian neural crest cells in vitro. Adhesion and migration
Ovarian cancer ascites-derived vitronectin and fibronectin: Combined purification, molecular features and effects on cell response
Carduner L, et al.
Biochim. Biophys. Acta Gen. Subj., 1830(10), 4885-4897 (2013)
Novel purification of vitronectin from human plasma by heparin affinity chromatography
Yatohgo T, et al.
Cell Structure and Function, 13(4), 281-292 (1988)
Phenotypic characterization of human smooth muscle cells derived from atherosclerotic tibial and peroneal arteries
Jones BA, et al.
Journal of Vascular Surgery, 24(5), 883-891 (1996)

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