U3885

UK-78282 monohydrochloride

≥98% (HPLC)

• 别名: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride
• 经验公式（希尔记法）: C₂₉H₃₅NO₂HCl
• CAS号: 136647-02-4
• 分子量: 466.05
• MDL號碼: MFCD16875438
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329827628
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: desiccated
• 顏色: white to off-white
• 溶解度: DMSO: >10 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• SMILES 字串: Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1
• InChI: 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
• InChI 密鑰: ZZSQARULZYQMIG-UHFFFAOYSA-N

说明

生化／生理作用

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H319,H400
• 防範說明: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• 危險分類: Aquatic Acute 1 - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable