推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
rat
技術
immunohistochemistry: suitable
western blot (chemiluminescent): suitable
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TRPC1(7220)
mouse ... Trpc1(22063)
rat ... Trpc1(89821)
一般說明
Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.
免疫原
Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.
生化／生理作用
Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca2+ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.
外觀
Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2
安全危害
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing
Selli C
Molecular and Cellular Biochemistry, 420, 129-140 (2016)
Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
Chen K
Endocrine Research, 38, 59-68 (2013)
Wanjie Huang et al.
International journal of molecular medicine, 49(2) (2021-12-23)
Persistent pulmonary hypertension of the newborn (PPHN) is a common pulmonary vascular disease during the neonatal period, and it is associated with a high clinical mortality rate and a poor prognosis. At present, the treatment of PPHN is based mainly
Tamas Szikra et al.
The Journal of physiology, 586(20), 4859-4875 (2008-08-30)
Tonic synapses are specialized for sustained calcium entry and transmitter release, allowing them to operate in a graded fashion over a wide dynamic range. We identified a novel plasma membrane calcium entry mechanism that extends the range of rod photoreceptor
The Role of Transient Receptor Potential Cation Channel, Subfamily C, Member 1 in the Odontoblast-like Differentiation of Human Dental Pulp Cells
Song Z
Journal of Endodontics, 43, 315-320 (2017)
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