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生物源
synthetic
品質等級
描述
Oxidized form
化驗
≥99% (titration)
形狀
powder
溶解度
ethanol: soluble 50 mg/mL
SMILES 字串
OC(=O)CCCCC1CCSS1
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI 密鑰
AGBQKNBQESQNJD-UHFFFAOYSA-N
基因資訊
human ... ACHE(43) , BCHE(590)
rat ... Adra1a(29412) , Adra1b(24173) , Adra1d(29413)
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應用
α-LA可以恢复高脂肪喂养的糖尿病大鼠的内皮活动，并减轻氧化应激4。它还用于分析星形胶质细胞中的ROS 产生5。
生化／生理作用
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
準備報告
（±）-α-硫辛酸（α-LA）以 50mg/ml的浓度溶于乙醇
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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