T2580

Trapoxin A

≥98% (HPLC), from Helicoma ambiens

• 别名: Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl), RF 1023A
• 经验公式（希尔记法）: C₃₄H₄₂N₄O₆
• CAS号: 133155-89-2
• 分子量: 602.72
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 生物源: Helicoma ambiens
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: soluble 0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H₂O); chloroform: soluble; methanol: soluble
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• InChI: 1S/C34H42N4O6/c39-29(30-22-44-30)18-9-3-8-16-25-31(40)36-26(20-23-12-4-1-5-13-23)32(41)37-27(21-24-14-6-2-7-15-24)34(43)38-19-11-10-17-28(38)33(42)35-25/h1-2,4-7,12-15,25-28,30H,3,8-11,16-22H2,(H,35,42)(H,36,40)(H,37,41)/t25-,26-,27-,28+,30-/m0/s1
• InChI 密鑰: GXVXXETYXSPSOA-UFEOFEBPSA-N

说明

應用

Trapoxin A has been used:

• to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
• to study its effects on the inhibition of HDAC3 in human cell lines
• to study its effects on the inhibition of HDAC6 in rat pyramidal neurons

生化／生理作用

Trapoxin A is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. It increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin A irreversibly inhibites HDAC activity in crude cell lysates, and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.

特點和優勢

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準備報告

Trapoxin A is soluble in DMSO at a concentration ranging from 0.9-1.10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in chloroform and methanol.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P301 + P310
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable