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Merck

T123

Sigma-Aldrich

Thioperamide 马来酸盐

solid

别名:

MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide 马来酸盐

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About This Item

经验公式(希尔记法):
C15H24N4S · C4H4O4
分子量:
408.52
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

儲存條件

desiccated
under inert gas

顏色

white

溶解度

H2O: >10 mg/mL
DMSO: 12 mg/mL
ethanol: 3 mg/mL

SMILES 字串

OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3

InChI

1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI 密鑰

REZRBLGMJZZSID-BTJKTKAUSA-N

基因資訊

human ... HRH3(11255)

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應用

用马来酸硫代哌啶盐研究哺乳动物白色脂肪组织的交感 和自主神经 活动。

生化/生理作用

噻普酰胺是一种有效的选择性 H 3 组胺受体拮抗剂,可通过血脑屏障。它影响中枢组胺能系统,缩短小鼠癫痫和惊厥的持续时间。它还能改善其他药物(如东莨菪碱)引起的学习障碍。
强效和选择性 H 3 组胺受体拮抗剂,可通过血脑屏障。

特點和優勢

《受体分类和信号转导》手册的 组胺受体 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Jiao Shen et al.
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Previously, we showed that orexin-A, a 33-aa peptide, influences renal sympathetic nerve activity. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects of orexin-A on the sympathetic nerve
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Our previous study has shown that a single dose of S-1-propenylcysteine (S1PC) exerted an antihypertensive effect in spontaneously hypertensive rats (SHR), while its mode of action remained to be further investigated. The aim of this study was to explore the
H Yokoyama et al.
European journal of pharmacology, 234(1), 129-133 (1993-03-30)
The effect of thioperamide, a histamine H3 receptor antagonist, on electrically induced convulsions was studied in mice. Thioperamide significantly and dose dependently decreased the duration of each phase of convulsion and raised the electroconvulsive threshold. Its anticonvulsant effects were prevented
Jiao Shen et al.
Neuroscience letters, 441(1), 100-104 (2008-07-05)
Previously, we showed that l-carnosine, a bioactive dipeptide, influences the sympathetic nerve activity innervating kidney and brown adipose tissue. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects
S Miyazaki et al.
Life sciences, 57(23), 2137-2144 (1995-01-01)
We examined the effects of thioperamide and (R)-alpha-methylhistamine, a histamine H3-receptor antagonist and an agonist, respectively, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Thioperamide alone slightly improved the learning deficit induced by scopolamine, and pretreatment

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