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生物源
mouse
重組細胞
expressed in CHO cells
化驗
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
monomer 45 kDa by calculation
包裝
pkg of 100 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
<0.06 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Havcr2(171285)
一般說明
Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.
生化／生理作用
The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
外觀
Lyophilized from 0.2 μm-filtered solution in PBS.
重構
Reconstitute at 100 μg/mL in sterile PBS.
其他說明
The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
TIM-3 is Expressed on Activated Human CD4+ T Cells and Regulates Th1 and Th17 Cytokines
William D. Hastings
European Journal of Immunology, 39(9), 2492-2501 (2009)
TIM Proteins and Immunity
Lawrence P. Kane
Journal of Immunology, 184(6), 2743-2749 (2010)
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
Roselyn R
Proceedings of the National Academy of Sciences of the USA, 107.19, 8706-8711 (2010)
TIM-1 and TIM-3 Proteins in Immune Regulation
Ee Wern Su
Cytokine, 44(1), 9-13 (2008)
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Gordon J. Freeman
Immunological Reviews, 235(1), 172-189 (2010)
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