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生物源
human
重組細胞
expressed in E. coli
化驗
≥90% (SDS-PAGE)
形狀
liquid
分子量
20.4 kDa (181 aa, 19-161 aa + His Tag)
包裝
pkg of 50 μg
濃度
0.25 mg/mL
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... TREM2(54209)
一般說明
TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
外觀
0.25 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Qian Zhai et al.
Anesthesiology, 127(1), 98-110 (2017-04-12)
Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days
Hyuk Sung Kwon et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 73, 215-218 (2020-02-19)
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic
Francesca Cignarella et al.
Acta neuropathologica, 140(4), 513-534 (2020-08-11)
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2
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