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Merck
所有图片(1)

主要文件

SRP6159

Sigma-Aldrich

FGF-basic human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

别名:

FGF-2, FGF-b, HBGF-2, HBGH-2, Prostatropin

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About This Item

CAS号:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in human cells

化驗

≥95% (SDS-PAGE)

形狀

lyophilized

分子量

17 kDa (monomer, non-glycosylated)

包裝

pkg of 10 μg

技術

cell culture | mammalian: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... FGF2(2247)

一般說明

FGF-basic is a member of the fibroblast growth factor (FGF) family. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. The gene encoding this protein is localized on human chromosome 4q28.

生化/生理作用

FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The protein associates with fibroblast growth factor receptors 1, 2 and 3 (FGFR-1, -2, -3).

外觀

Lyophilized from a PBS solution.

準備報告

Centrifuge the vial prior to opening.

重構

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Cigdem Usul Afsar et al.
International journal of clinical and experimental pathology, 8(9), 9760-9771 (2015-12-01)
Non-small cell lung carcinoma is the leading cause of cancer related to death in the world. Squamous cell lung carcinoma (SqCLC) is the second most frequent histological subtype of lung carcinomas. Recently, growth factors, growth factor receptors, and signal transduction
Yuriko Katoh et al.
International journal of molecular medicine, 17(3), 529-532 (2006-02-09)
WNT, FGF and Hedgehog signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. FGF16, FGF18, and FGF20 genes are targets of WNT-mediated TCF/LEF-beta-catenin-BCL9/BCL9L-PYGO transcriptional complex. SPROUTY (SPRY) and SPRED family genes encode inhibitors for receptor tyrosine kinase signaling cascades
Mingming Hu et al.
PloS one, 11(1), e0147374-e0147374 (2016-01-30)
Basic fibroblast growth factor (bFGF) is known to stimulate angiogenesis and thus to influence the proliferation, migration and survival of tumor cells. Many studies examined the relationship between human bFGF overexpression and survival in lung cancer patients, but the results
Arsenii Zabirnyk et al.
Frontiers in pharmacology, 11, 568764-568764 (2021-01-05)
Background: No pharmacological treatment exists to prevent or stop the calcification process of aortic valves causing aortic stenosis. The aim of this study was to develop a robust model of induced calcification in whole aortic valve leaflets which could be
Abha Sahni et al.
Blood, 104(12), 3635-3641 (2004-08-07)
We have shown previously that fibrin(ogen) binding potentiates the capacity of fibroblast growth factor 2 (FGF-2) to stimulate endothelial cell (EC) proliferation. We have now investigated the receptor requirement for EC proliferation by fibrinogen-bound FGF-2. ECs were cultured with 25

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