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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
17.0 kDa
包裝
pkg of 25 μg
雜質
endotoxin, tested
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IL36RN(26525)
一般說明
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36? (IL-1F6), IL-36? (IL-1F8), and IL-36? (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36?, -? or -? by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
生化／生理作用
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36? (IL-1F6), IL-36? (IL-1F8), and IL-36? (IL-1F9). Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
外觀
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jennifer E Towne et al.
The Journal of biological chemistry, 286(49), 42594-42602 (2011-10-04)
IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36Ra (formerly IL-1F5) has been reported to antagonize IL-36γ. However, our previous attempts to demonstrate
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