SRP3281

SCD30 LIGAND human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

• 别名: CD153, CD30L, TNFSF8
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥95% (HPLC); ≥95% (SDS-PAGE)
• 形狀: lyophilized
• 效力: 10.0-25.0 ng/mL
• 分子量: 30.0-50.0 kDa
• 包裝: pkg of 50 μg
• 雜質: <0.1 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: P28908
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... TNFSF8(944)

说明

一般說明

CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-KappaB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkins′s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain.

生化／生理作用

CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. Recombinant human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His -Tag.

外觀

Lyophilized from 1x PBS.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable