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生物源
rat
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
效力
≤0.2 ng/mL ED50
分子量
18.7 kDa
包裝
pkg of 10 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
rat ... THPO(81811)
相关类别
一般說明
Thrombopoietin (TPO) also known as c-Mpl ligand is an acidic glycoprotein expressed mainly in the liver, kidney, and bone marrow. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7kDa), which contains the erythropoietin-like domain of the full length TPO protein.
應用
Thrombopoietin (TPO) from rat has been used in experimental systems to determine the effect of TPO in recovery from thrombocytopenia.
生化／生理作用
Thrombopoietin (TPO) acts as a key physiologic regulator of megakaryocyte and platelet production in vivo. Mutation of TPO or its receptor might lead to thrombocytopenia and megakaryocytopoiesis. In addition, TPO also influence the action of erythroid and erythromegakaryocytic progenitors in mouse embryonic yolk sac. TPO binds to c-mpl receptor and regulates circulating platelet level.
序列
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
外觀
Lyophilized from 5 mM Sodium Phosphate, pH 7.6 + 75 mM NaCl.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Reactivation of a hematopoietic endocrine program of pregnancy contributes to recovery from thrombocytopenia.
Bhattacharyya S
Molecular Endocrinology, 16(6), 1386-1393 (2002)
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.
Kuter DJ and Begley CG
Blood, 100(10), 3457-3469 (2002)
Thrombopoietin: the primary regulator of platelet production.
Kaushansky K
Blood, 86(2), 419-431 (1995)
Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.
Foster DC
Proceedings of the National Academy of Sciences of the USA, 91(26), 13023-13027 (1994)
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.
Lok S
Nature, 369(6481), 565-568 (1994)
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