SRP2147

CAR-LBD (101-348), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• 别名: CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• 分類程式碼代碼: 12352202
• NACRES: NA.26

属性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥70% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~55.3 kDa
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: 100 μg/mL
• 顏色: clear; colorless
• NCBI登錄號: NM_005122
• UniProt登錄號: Q14994
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... NR1I3(9970)

说明

一般說明

The gene encoding this protein is localized on human chromosome 1q23.3.

生化／生理作用

It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable