推荐产品
一般說明
肿瘤坏死因子α（TNFα或 TNFSF2）由映射到人类染色体 6p21.33 的基因编码。
生化／生理作用
肿瘤坏死因子 α（TNFα或 TNFSF2）由许多不同类型的细胞产生，包括活化单核细胞、成纤维细胞、内皮细胞、巨噬细胞、T 细胞、B 淋巴细胞、粒细胞、平滑肌细胞、嗜酸性粒细胞、软骨细胞和其他细胞类型。作为一种细胞因子参与细胞增殖、分化、凋亡、脂质代谢和凝血。高水平 TNFα导致炎症反应的发生，而炎症反应是许多疾病的特征，包括自身免疫性疾病、胰岛素抵抗和癌症。TNFα 的活性形式（18 kDa）是由前体蛋白 76-77 位残基之间的 Ala-Val 键断裂产生的。
外觀
无色澄清冷冻液体
準備報告
使用手动除霜冰柜，避免反复冻融循环。工作时，请将样品置于冰上。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Bharat B Aggarwal
Nature reviews. Immunology, 3(9), 745-756 (2003-09-02)
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins
Alasdair J Edgar et al.
Respiratory research, 7, 1-1 (2006-01-05)
To elucidate further the pathogenesis of sporadic, idiopathic pulmonary arterial hypertension (IPAH) and identify potential therapeutic avenues, differential gene expression in IPAH was examined by suppression subtractive hybridisation (SSH). Peripheral lung samples were obtained immediately after removal from patients undergoing
A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
Bos SD
European Journal of Human Genetics, 18, 953-959 (2010)
Hao Zhu et al.
Frontiers in cell and developmental biology, 9, 642437-642437 (2021-03-26)
Low back pain is tightly associated with intervertebral disc degeneration (IVDD) and aberrant nucleus pulposus (NP) is a critical cause. miRNAs N6-methyladenosine (m6A) modification accounts for the TNF-α-induced senescence of NP cells. The aim of this study was to investigate
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley et al.
Cell, 104(4), 487-501 (2001-03-10)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门