SRP2097

HIF-1 α, C-terminal activation domain (776-826 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• 别名: HIF-1alpha, HIF1, HIF1-alpha, MOP1, PASD8, bHLHe78
• 分類程式碼代碼: 12352200
• NACRES: NA.26

属性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥85% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~6.7 kDa
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: 700 μg/mL
• 顏色: colorless to clear
• NCBI登錄號: NM_001530
• UniProt登錄號: Q16665
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... HIF1A(3091)

说明

一般說明

The gene encoding it is localized on human chromosome 14q23.2.

生化／生理作用

During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation.

Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains located between amino acids 531 and 826. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. Specific disruption of the HIF-1 pathway is important for exploring its role in tumor biology and developing more efficient weapons to treat cancer. HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). HIF-1alpha protein expression often seen in invasive breast cancer. Recent data demonstrates that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells and suggest a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable