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生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥87% (SDS-PAGE)
形狀
aqueous solution
分子量
67 kDa
包裝
pkg of 20 μg
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... TDP2(51567)
一般說明
Human tyrosyl DNA phosphodiesterase 2, or TDP2 (GenBank Accession No. NM_016614) full length with N-terminal His-GST-tag, MW = 67 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
外觀
Formulated in 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 200 mM Imidazole, 20% Glycerol, and 3 mM DTT.
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
Christophe Marchand et al.
Molecular cancer therapeutics, 13(8), 2116-2126 (2014-07-16)
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I-, alkylation-, and chain terminator-induced DNA
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