生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥44% (SDS-PAGE)
形狀
aqueous solution
分子量
65 kDa
包裝
pkg of 50 μg
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... SESN1(27244)
一般說明
Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454) full length, amino acids 2-551(end) with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
應用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
Andrei V Budanov et al.
Cell, 134(3), 451-460 (2008-08-12)
The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose activity is inhibited by the TSC1:TSC2 complex.
Jun Hee Lee et al.
Science (New York, N.Y.), 327(5970), 1223-1228 (2010-03-06)
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit activation of target of rapamycin (TOR). We show that the abundance of Drosophila sestrin (dSesn) is increased upon chronic TOR activation
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