生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥90% (SDS-PAGE)
形狀
aqueous solution
分子量
40.1 kDa
包裝
pkg of 10 μg
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... NEK6(10783)
一般說明
Human NEK6 (GenBank Accession No. NM_014397), amino acids 1-313 with N-terminal HIS6-tag, MW=40.1 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
應用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
單位定義
One unit is defined as the amount of enzyme that will phosphorylate 1 nmol NEK6 substrate (FLAKSFGSPNRAYKK) per minute at pH 7.4 and 30°C.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Min-Jean Yin et al.
The Journal of biological chemistry, 278(52), 52454-52460 (2003-10-18)
The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase required for the initiation of mitosis, whereas its inactivation is necessary for mitotic exit. Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for
Christopher Belham et al.
The Journal of biological chemistry, 278(37), 34897-34909 (2003-07-04)
The Nek family of protein kinases in humans is composed of 11 members that share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and divergent carboxyl-terminal tails of varying
Laura O'Regan et al.
The Journal of cell biology, 209(3), 349-358 (2015-05-06)
Hsp70 proteins represent a family of chaperones that regulate cellular homeostasis and are required for cancer cell survival. However, their function and regulation in mitosis remain unknown. In this paper, we show that the major inducible cytoplasmic Hsp70 isoform, Hsp72
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