SML3825

MM0299

≥98% (HPLC)

• 别名: 4,4a,5,5a,6,6a-Hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione
• 经验公式（希尔记法）: C₂₆H₂₃NO₅
• CAS号: 474255-10-2
• 分子量: 429.46
• MDL號碼: MFCD03145757
• 分類程式碼代碼: 51111800
• 分類程式碼代碼: 12352200
• NACRES: NA.21

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C

说明

生化／生理作用

MM0299 is a cell penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable