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Merck

SML3817

Sigma-Aldrich

TLR2-IN-C29

≥98% (HPLC)

别名:

3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methylbenzoic acid, C29

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About This Item

经验公式(希尔记法):
C16H15NO4
分子量:
285.29
分類程式碼代碼:
51111800
分類程式碼代碼:
12352200
NACRES:
NA.21

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow to orange

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

-10 to -25°C

SMILES 字串

O=C(C1=C(C)C(N=CC2=C(O)C(OC)=CC=C2)=CC=C1)O

生化/生理作用

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist that inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain
Proceedings of the National Academy of Sciences of the USA, 112(17), 5455-5460 (2015)

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